Amsterdam, The Netherlands, December 6, 2020 – Kiadis Pharma N.V. (“Kiadis” or the “Company”) (Euronext Amsterdam and Brussels: KDS), a clinical-stage biopharmaceutical company developing innovative NK-cell-based medicines for the treatment of life-threatening diseases, announces that new data related to its K-NK cell therapy platform will be presented at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition being held virtually from December 5-8, 2020. Abstract #68 is an oral presentation with data showing that multiple infusions of ex vivo expanded haploidentical NK cells in R/R AML patients yielded unprecedented outcomes with no safety reactions or toxicities. The poster for abstract #825 presents data that demonstrate NKTR-255 significantly enhanced the ADCC of expanded NK cells with anti-CD20 type I and type II antibodies against Chronic Lymphocytic Leukemia (CLL), Follicular Lymphoma (FL), and rituximab-resistant BL cells. Three additional posters, abstracts #2151, #2341, and #2347, provide details of ongoing studies within the K-NK cell therapy programs.
~Five presentations related to Kiadis’ K-NK cell therapy platform will be presented at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition~
- Oral presentation (abstract #68) presents data that show multiple infusions of FC21-NK cells in patients with relapsed and refractory acute myeloid leukemia (R/R AML) yielded impressive outcomes with no infusion reactions or toxicities
- Poster presentation (abstract #825) describes data demonstrating NKTR-255 significantly enhanced the ADCC of expanded NK cells with anti-CD20 type I and type II antibodies against CLL, FL and rituximab-resistant BL cells
- Poster presentation (abstract #2151) provides details of a phase I pilot study in CML patients to evaluate safety and examine if adding K-NK003 to ongoing Tyrosine kinase inhibitors (TKI) therapy leads to achieving MRD negative status
- Poster presentation (abstract #2341) provides the details of the ongoing phase II trial, NK-REALM, investigating the safety and efficacy of K-NK002 for the treatment of patients with high-risk AML or MDS undergoing haploidentical bone marrow transplantation
- Poster presentation (abstract #2347) describes the phase I study testing the safety of FC21-expanded, off-the-shelf NK cells for treatment of R/R AML and MDS